Ahh the virtues of half bottles!
1. less impact from TCA/Spoilage/etc (one $100 750ml bottle of corked wine < two $50 375ml bottles of wine, of which one is corked)
2. more chances to diversify your cellar (explore regions, producers, take gambles, etc)
3. more accessible young (pls see Quevedo 2011 if you don't believe me)
4. more romantic (e.g., if you finish a meal for 2 with a 750 of port, either you're the one taking your trousers off, or they're staying on entirely, whereas...)
In terms of the 'science' of the aging curve, that's beyond my pay grade. I am still very much enjoying 80Ds, 86Gms, 91GCs, 94Ws, and several other 375s that have been available in quantity from the US. My oldest 375 is a 45 (47?) Warre (Dow?) which I would be happy to share at a suitable occasion. My youngest 375s would be the 300 2011s I purchased from Jeff/Oscar
incidentally, those have retained a freshness and accessibly that has been sucked out of their 750ml cousins (to my palate, at least). Again, I would be happy to organize a 375/750/6L tasting of Quevedo in NYC, LON, both, or Other. I could also do 375/750/1.5 of Dow 80, and/or of Taylor 77, if memory serves.
Port pros seem to scoff a 375s. Happily, that just means more for Christopher!